@article{120,
  keywords = {in vivo imaging; microglial calcium signalling; midlife; sexual dimorphism; transcriptomics.},
  author = {Pan K and Garaschuk O},
  title = {The role of intracellular calcium stores-mediated calcium signals for in vivo sensor and effector functions of microglia},
  abstract = {Under physiological conditions microglia, the immune sentinels of the brain, constantly monitor their microenvironment. In the case of danger, damage, or cell/tissue dyshomeostasis they react with changes in process motility, polarisation, directed process movement, morphology and gene expression profile, release pro- and anti-inflammatory mediators, proliferate, and clean brain parenchyma by means of phagocytosis. Based on recent transcriptomic and in vivo Ca2+ imaging data, we argue that the local cell/tissue dyshomeostasis is sensed by microglia via intracellular Ca2+ signals, many of which are mediated by Ca2+ release from the intracellular Ca2+ stores. These signals encode the strength, the duration, and the spatiotemporal pattern of the stimulus and, at the same time, relay this information further to trigger the respective Ca2+ -dependent effector pathways. We also point to the fact that the microglial Ca2+ signalling is sexually dimorphic and undergoes profound changes across the organism's lifespan. Interestingly, the first changes in microglial Ca2+ signalling are visible already in 9-11 months old mice, roughly corresponding to 40 years old humans. This article is protected by copyright. All rights reserved.},
  year = {2022},
  journal = {J. Physiol},
  month = {03/2022},
  url = {https://pubmed.ncbi.nlm.nih.gov/35315518/},
}