Large-scale oscillatory calcium waves in the immature cortex

Bibcite
Author
O Garaschuk
J. Linn
J Eilers
A Konnerth
Keywords
*Calcium Signaling/drug effects
Calcium/*metabolism
Bicuculline/pharmacology
6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
Tetrodotoxin/pharmacology
Support, Non-U.S. Gov't
Receptors, N-Methyl-D-Aspartate/physiology
Receptors, GABA/physiology
In Vitro
Hippocampus/cytology/drug effects/growth & development/metabolism
GABA Antagonists/pharmacology
GABA/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Electric Conductivity
Cerebral Cortex/cytology/drug effects/*growth & development/*metabolism
Receptors, AMPA/physiology
Rats, Wistar
Rats
Photons
Neurons/drug effects/metabolism
Nerve Net/drug effects/metabolism
Membrane Potentials/drug effects
Animals, Newborn
Animal
Abstract

Two-photon imaging of large neuronal networks in cortical slices of newborn rats revealed synchronized oscillations in intracellular Ca2+ concentration. These spontaneous Ca2+ waves usually started in the posterior cortex and propagated slowly (2.1 mm per second) toward its anterior end. Ca2+ waves were associated with field-potential changes and required activation of AMPA and NMDA receptors. Although GABAA receptors were not involved in wave initiation, the developmental transition of GABAergic transmission from depolarizing to hyperpolarizing (around postnatal day 7) stopped the oscillatory activity. Thus we identified a type of large-scale Ca2+ wave that may regulate long-distance wiring in the immature cortex.
Year of Publication
2000
Journal
Nat Neurosci
Volume
3
Number of Pages
452-459
URL
http://www.ncbi.nlm.nih.gov/cgi-bin/Entrez/referer?http://www.nature.com/cgi-taf/DynaPage.taf%3ffile=/neuro/journal/v3/n5/full/nn0500_452.html
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