[Effect of trans-ACPD, a specific agonist of glutamate interacting with metabotropic receptors, on synaptic transmission in the rat hippocampus]

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Author	O. Garaschuk Koval'chuk Yu O. Kryshtal
Keywords	Cycloleucine-pharmacology Glutamic-Acid Cycloleucine 1-amino-1,3-dicarboxycyclopentane Receptors,-Neurotransmitter Receptors,-Glutamate Glutamates Synaptic-Transmission-drug-effects Synapses-drug-effects Receptors,-Neurotransmitter-drug-effects Hippocampus-drug-effects Glutamates-metabolism Cycloleucine-analogs-and-derivatives Rats- Membrane-Potentials-drug-effects Evoked-Potentials-drug-effects English-Abstract
Abstract	Trans-ACPD, a cyclic analogue of glutamate, has been studied for its influence on field potentials and excitatory postsynaptic currents (EPSCs) in the CA1 layer. Being applied in concentration 50 microM and above, trans-ACPD completely and reversibly inhibited excitatory postsynaptic field potentials but has no effect on EPSCs. Trans-ACPD in the same concentration reversibly reduced the amplitude of antidromic population spike in the CA1 layer, but has an insignificant effect on antidromic population spike in the CA3 layer.
Year of Publication	1992
Journal	Neurofiziologiia
Volume	24
Number of Pages	211-214
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